Neurodegenerative diseases and oxidative stress
Identifieur interne : 001601 ( Main/Exploration ); précédent : 001600; suivant : 001602Neurodegenerative diseases and oxidative stress
Auteurs : Kevin J. Barnham [Australie] ; Colin L. Masters [Australie] ; Ashley I. Bush [Australie, États-Unis]Source :
- Nature Reviews Drug Discovery [ 1474-1776 ] ; 2004-03.
Abstract
Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for utilizing this essential element. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. The systems in place to cope with the biochemistry of oxygen are complex, and many questions about the mechanisms of oxygen regulation remain unanswered. However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metalprotein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies.
Url:
DOI: 10.1038/nrd1330
Affiliations:
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Bush</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8D4A2D7360190722A3A85EA46F3111691B7E0804</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1038/nrd1330</idno><idno type="url">https://api.istex.fr/document/8D4A2D7360190722A3A85EA46F3111691B7E0804/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001198</idno><idno type="wicri:Area/Main/Curation">000F99</idno><idno type="wicri:Area/Main/Exploration">001601</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Neurodegenerative diseases and oxidative stress</title><author><name sortKey="Barnham, Kevin J" sort="Barnham, Kevin J" uniqKey="Barnham K" first="Kevin J." last="Barnham">Kevin J. Barnham</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, The University of Melbourne, and The Mental Health Research Institute of Victoria, Victoria 3010</wicri:regionArea><wicri:noRegion>Victoria 3010</wicri:noRegion></affiliation></author><author><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, The University of Melbourne, and The Mental Health Research Institute of Victoria, Victoria 3010</wicri:regionArea><wicri:noRegion>Victoria 3010</wicri:noRegion></affiliation></author><author><name sortKey="Bush, Ashley I" sort="Bush, Ashley I" uniqKey="Bush A" first="Ashley I." last="Bush">Ashley I. Bush</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, The University of Melbourne, and The Mental Health Research Institute of Victoria, Victoria 3010</wicri:regionArea><wicri:noRegion>Victoria 3010</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Laboratory for Oxidation Biology, Genetics and Aging Research Unit and Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital East, Charlestown, Massachusetts 02129</wicri:regionArea><wicri:noRegion>Massachusetts 02129</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Nature Reviews Drug Discovery</title><idno type="ISSN">1474-1776</idno><idno type="eISSN">1474-1784</idno><imprint><publisher>Nature Publishing Group</publisher><date type="published" when="2004-03">2004-03</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="205">205</biblScope><biblScope unit="page" to="214">214</biblScope></imprint><idno type="ISSN">1474-1776</idno></series><idno type="istex">8D4A2D7360190722A3A85EA46F3111691B7E0804</idno><idno type="DOI">10.1038/nrd1330</idno><idno type="ArticleID">nrd1330</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1474-1776</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially dangerous, and a complex system of checks and balances exists for utilizing this essential element. Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. The systems in place to cope with the biochemistry of oxygen are complex, and many questions about the mechanisms of oxygen regulation remain unanswered. However, this same complexity provides a number of therapeutic targets, and different strategies, including novel metalprotein attenuating compounds, aimed at a variety of targets have shown promise in clinical studies.</div></front></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Barnham, Kevin J" sort="Barnham, Kevin J" uniqKey="Barnham K" first="Kevin J." last="Barnham">Kevin J. Barnham</name></noRegion><name sortKey="Bush, Ashley I" sort="Bush, Ashley I" uniqKey="Bush A" first="Ashley I." last="Bush">Ashley I. Bush</name><name sortKey="Masters, Colin L" sort="Masters, Colin L" uniqKey="Masters C" first="Colin L." last="Masters">Colin L. Masters</name></country><country name="États-Unis"><noRegion><name sortKey="Bush, Ashley I" sort="Bush, Ashley I" uniqKey="Bush A" first="Ashley I." last="Bush">Ashley I. Bush</name></noRegion><name sortKey="Bush, Ashley I" sort="Bush, Ashley I" uniqKey="Bush A" first="Ashley I." last="Bush">Ashley I. Bush</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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